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--- This year brought 26 biosimilars that were approved by the FDA A significant portion of them (16) were denosumab biosimilars: 8 biosimilars referencing Prolia (denosumab for osteoporosis) Additional 8 biosimilars referencing Xgeva (denosumab for cancer-related bone disease) The downstream effects compound: Biosimilars typically reduce costs by 15-35% compared to reference products (this can decrease more as additional biosimilar options become available) Price competition benefits the entire therapeutic category Patients who couldn't afford brand therapy now have accessible options Health systems gain formulary flexibility without compromising clinical outcomes --- The 26 biosimilar approvals in 2025 represent thousands of patients gaining affordable access to proven therapies that may have previously been out of reach

Blood pressure elevation in obesity stems from multiple mechanisms

You can avoid the big sugar spikes and crashes that make you feel tired and crave sugary treats

The Prawn Cocktail Years duo, Simon Hopkinson and Lindsey Bareham, and Annie Bells Baking Bible plump for much richer affairs, with the former going for melted chocolate as well as the more usual cocoa, plus butter, and Bell adding fromage frais as well

That is more than has typically been seen with currently licensed options such as Wegovy and Mounjaro

MAFLD is diagnosed based on the presence of steatosis on images, histological findings, or serum marker levels as well as the presence of at least one of the three metabolic features: overweight/obesity, type 2 diabetes mellitus, and metabolic risk factors